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Anabolic steroids also work to block some of the impact of cortisol on muscle tissue, which works to slow the rate at which existing muscle tissue is broken down, according to scientists at Columbia University. This might explain why a high dose of these drugs would actually take time and effort to get rid of excess fat. "If you are in a state during which cortisol is so important to the way your body works, it follows that some of it is going to be absorbed as fat," says Richard F. Green, PhD, professor of psychology at Columbia University Medical Center. "But if the body was not sensitive to cortisol, then there is no reason to expect that some of it would simply leave through fat absorption, leaving the fat." As with any drug, some people are more sensitive to the effects of these steroids than others. "If you are taking an anti-androgen, for example, you are going to be more likely to respond to a drug like Trenbolone or Dianabol than you are to an anti-androgen like Trenbolone or Tren-Ab," Green says. Green says that people who have a certain hormone system in their bodies are more susceptible to this effect "because we are all predisposed to this." One of the commonest reasons why people take amphetamines as well as testosterone is for their "muscle-building" effects, Green says. People who have a lot of muscle mass and a few inches of definition, he says, "are going to have a lot more of these drugs in their systems; not just amphetamines, but other steroids." Some of the people affected by this increase in steroid levels are women with a history of abuse who feel that they can't continue with traditional gynecological examinations. "These drugs don't cause menopausal breast disease," Green says, "so it would seem to add an additional advantage – a women's advantage." The body can metabolize these hormones differently, so one study showed that amphetamines could increase circulating estrogen levels by a quarter compared to a saline placebo – but not testosterone levels. So some people have their estrogen levels lowered after exposure to a certain dose of these drugs, but this doesn't explain why some women might actually be more sensitive to the same amphetamine-like chemicals than others – since the amount of estrogen produced by the body would have to increase by more than a quarter just to compare to the effect testosterone. "But it may be true that some of the women that are most sensitive to these drugs have higher levels" of testosterone and estrogen than the average person, Green says. Another reason Similar articles: